A Case of Toxic Epidermal Necrolysis Treated with High Dose Intravenous Immunoglobulin / 대한피부과학회지
Korean Journal of Dermatology
;
: 940-944, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-131961
ABSTRACT
Toxic epidermal necrolysis(TEN) is the most dramatic, life-threatening cutaneous drug reaction. TEN is characterized by extensive detachment of the epidermis undergoing full-thickness necrosis. The pathogenetic pathway and specific treatments of TEN have not yet been identified. Recently, several reports suggested that apoptosis in TEN is promoted by proteins such as Fas antigen and high dose intravenous immunoglobulin(IVIG) inhibits Fas-mediated cell death by blocking the Fas receptor. We report a case of TEN in a 26-year-old woman who had been treated with prednisolone due to iritis. She was treated with high dose IVIG(0.4g/Kg/day for 4 days one day and 0.7g/Kg/day for consecutive). In our case, the progression of skin lesion was interrupted after IVIG infusion and favorable vital outcome was achieved with mild adverse effects.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peau
/
Immunoglobulines
/
Prednisolone
/
Iritis
/
Syndrome de Stevens-Johnson
/
Immunoglobulines par voie veineuse
/
Mort cellulaire
/
Apoptose
/
Antigènes CD95
/
Épiderme
Type d'étude:
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Dermatology
Année:
2000
Type:
Article
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