The Different Mechanisms of Awake Micturitions between Male and Female Rats Using an Overactive Model with Intravesical PGE2 Instillation / 대한비뇨기과학회지

ABSTRACT

PURPOSE: We wanted to obtain informations on the different mechanisms of awake micturitions between male and female rats by using an overactive model with intravesical PGE2 instillation. MATERIALS AND METHODS: Sprague Dawley rats(6 male, 6 female) were used. A catheter was implanted into the bladder to record the intravesical pressure. Three days later, the awake cystometry was performed, and PGE2 was given intravesically to induce detrusor overactivity(DO). With using the conventional pressure and volume parameters, a new parameter of flow pressure was investigated. RESULTS: When recorded as the flow pressure, the male rats exhibited higher urethral resistance than did the female rats in the normal state. The male rats showed higher urethral resistances after DO was induced, than those before the DO. However, the female rats did not show increased urethral resistance after DO was induced. CONCLUSIONS: An increase in urethral resistance through the outlet region was induced in male rats after intravesical PGE2 instillation, but this didn't occur in female rats. This result indicates that overactive bladder has different mechanisms and responses in different genders.