Diabetic Macular Edema Before and After Intravitreal Triamcinolone Injection
Korean Journal of Ophthalmology
;
: 95-99, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-134234
ABSTRACT
PURPOSE:
To compare intravitreal triamcinolone acetonide (IVT) versus natural course in refractory diabetic macular edema.METHODS:
In a prospective interventional case series, twenty five eyes with refractory DME which had been allocated to the sham group of a previous clinical trial underwent new examination and optical coherence tomography about 9 months after their first enrollment. Twenty eyes that met the inclusion criteria, visual acuity (VA) 200 micrometer, were treated by 4 mg IVT. Evaluations were repeated at 2 and 4 months post-injection to imitate the similar examination intervals after sham injection. Corrected visual acuity and macular thickness changes following IVT were compared to the corresponding changes after sham injection (the natural course).RESULTS:
Visual acuity changes within and between each period were not statistically significant. Visual acuity decreased 0.08 & 0.09 logMAR by 2 months and 0.06 & 0.04 logMAR by 4 months after sham and IVT injections, respectively. The changes of macular thickness after IVT and sham intervention were not meaningful either. However, the difference between thickness changes by 4 months (52+/-50 micrometer increase after sham vs. 262+/-115 micrometer reduction after IVT) was significant (P=0.014).CONCLUSIONS:
Concerning macular thickness, IVT has beneficial effect on refractory diabetic macular edema as opposed to observation. However, considering visual acuity, it does not induce significant difference in comparison to the natural course of the disease.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Facteurs temps
/
Corps vitré
/
Triamcinolone acétonide
/
Acuité visuelle
/
Oedème maculaire
/
Études prospectives
/
Études de suivi
/
Résultat thérapeutique
/
Tomographie par cohérence optique
/
Rétinopathie diabétique
Type d'étude:
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Korean Journal of Ophthalmology
Année:
2007
Type:
Article
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