Identification of a Variant Form of Cellular Inhibitor of Apoptosis Protein (c-IAP2) That Contains a Disrupted Ring Domain
Immune Network
; : 137-141, 2002.
Article
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| WPRIM
| ID: wpr-134613
Responsable en Bibliothèque :
WPRO
ABSTRACT
Among the members of the inhibitor of apoptosis (IAP) protein family, only Livin and survivin have been reported to have variant forms. We have found a variant form of c-IAP2 through the interaction with the X protein of HBV using the yeast two-hybrid system. In contrast to the wild-type c-IAP2, the variant form has two stretches of sequence in the RING domain that are repeated in the C-terminus that would disrupt the RING domain. We demonstrate that the variant form has an inhibitory effect on TNF-mediated NF-kappaB activation unlike the wild-type c-IAP2, which increases TNF- mediated NF-kappaB activation. These results suggest that this variant form has different activities from the wild-type and the RING domain may be involved in the regulation of TNF-induced NF-kappaB activation.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Facteur de transcription NF-kappa B
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Apoptose
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Techniques de double hybride
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Facteur-2 associé aux récepteurs de TNF
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Facteur-6 associé aux récepteurs de TNF
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Protéines IAP
Type d'étude:
Diagnostic_studies
/
Prognostic_studies
Limites du sujet:
Humans
langue:
En
Texte intégral:
Immune Network
Année:
2002
Type:
Article