Paclitaxel-Cisplatin regimen as First-Line Chemotherapy after Cytoreductive Surgery in Patients with Epithelial Ovarian Cancer / 대한산부인과학회잡지
Korean Journal of Obstetrics and Gynecology
;
: 2263-2268, 2001.
Article
Dans Coréen
| WPRIM
| ID: wpr-134895
ABSTRACT
OBJECTIVE:
The purpose of this retrospective study is to assess the efficacy and toxicity of paclitaxel/cisplatin as first-line chemotherapy after cytoreductive surgery in patients with epithelial ovarian cancer. MATERIAL &METHODS:
From November 1999 to April 2001, 31 patients with histologically-proven epithelial ovarian cancer not previously treated with chemotherapy entered the study. FIGO stage IA or IB and grade 1 or 2 tumors were excluded. A comprehensive staging was performed during initial laparotomy. Paclitaxel was administered at a dose of 135 mg/m2, intravenously with cisplatin (75 mg/m2) every 3 weeks for 6 planned cycles, with prophylactic oral dexamethasone regimen (20 mg b.i.d.). The response of patients was evaluated with tumor markers and CT before and after chemotherapy. Responses and toxicities were defined according to the Gynecologic Oncology Group (GOG) criteria.RESULTS:
The overall response rates were 73% (16/22) in patients with residual disease after cytoreductive surgery (complete response, 64%; partial response, 9%). The median survival was 18 months. Grade 3/4 neutropenia and neuropathy (grade 2) were observed in 16 (52%), 12 (39%) patients, respectively.CONCLUSION:
The combination of paclitaxel and cisplatin is a well tolerated regimen with significant activity in the treatment of epithelial ovarian carcinoma after surgery.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs de l'ovaire
/
Dexaméthasone
/
Marqueurs biologiques tumoraux
/
Études rétrospectives
/
Cisplatine
/
Paclitaxel
/
Traitement médicamenteux
/
Laparotomie
/
Neutropénie
Type d'étude:
Étude observationnelle
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Obstetrics and Gynecology
Année:
2001
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS