LL-37 inhibits serum amyloid A-induced IL-8 production in human neutrophils
Experimental & Molecular Medicine
;
: 325-333, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-136589
ABSTRACT
Serum amyloid A (SAA) has been regarded as an important mediator of inflammatory responses. The effect of several formyl peptide receptor-like 1 (FPRL1) ligands on the production of IL-8 by SAA was investigated in human neutrophils. Among the ligands tested, LL-37 was found to specifically inhibit SAA-induced IL-8 production in transcriptional and post-transcriptional levels. Since SAA stimulated IL-8 production via ERK and p38 MAPK in human neutrophils, we tested the effect of LL-37 on SAA induction for these two MAPKs. LL-37 caused a dramatic inhibition of ERK and p38 MAPK activity, which is induced by SAA. LL-37 was also found to inhibit SAA-stimulated neutrophil chemotactic migration. Further, the LL-37-induced inhibitory effect was mediated by FPRL1. Our findings indicate that LL-37 is expected to be useful in the inhibition of SAA signaling and for the development of drugs against SAA-related inflammatory diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Transcription génétique
/
Protéine amyloïde A sérique
/
Transduction du signal
/
Mouvement cellulaire
/
Chimiotaxie des leucocytes
/
Interleukine-8
/
Protéines proto-oncogènes
/
MAP Kinase Kinase Kinases
/
Peptides antimicrobiens cationiques
/
Lignée cellulaire tumorale
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2009
Type:
Article
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