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A Novel Synthetic Compound 3-Amino-3-(4-Fluoro-Phenyl)-1H-Quinoline-2,4-Dione (KR22332) Exerts a Radioprotective Effect via the Inhibition of Mitochondrial Dysfunction and Generation of Reactive Oxygen Species
Yonsei Medical Journal ; : 886-894, 2014.
Article Dans Anglais | WPRIM | ID: wpr-137016
ABSTRACT

PURPOSE:

Acute side effects of radiation such as oral mucositis are observed in most patients. Although several potential radioprotective agents have been proposed, no effective agent has yet been identified. In this study, we investigated the effectiveness of synthetic compound 3-amino-3-(4-fluoro-phenyl)-1H-quinoline-2,4-dione (KR22332) as a radioprotective agent. MATERIALS AND

METHODS:

Cell viability, apoptosis, the generation of reactive oxygen species (ROS), mitochondrial membrane potential changes, and changes in apoptosis-related signaling were examined in human keratinocyte (HaCaT).

RESULTS:

KR22332 inhibited irradiation-induced apoptosis and intracellular ROS generation, and it markedly attenuated the changes in mitochondrial membrane potential in primary human keratinocytes. Moreover, KR22332 significantly reduced the protein expression levels of ataxia telangiectasia mutated protein, p53, and tumor necrosis factor (TNF)-alpha compared to significant increases observed after radiation treatment.

CONCLUSION:

KR22332 significantly inhibited radiation-induced apoptosis in human keratinocytes in vitro, indicating that it might be a safe and effective treatment for the prevention of radiation-induced mucositis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Radioprotecteurs / Kératinocytes / Survie cellulaire / Espèces réactives de l'oxygène / Apoptose / Lignée cellulaire tumorale / Potentiel de membrane mitochondriale Type d'étude: Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Radioprotecteurs / Kératinocytes / Survie cellulaire / Espèces réactives de l'oxygène / Apoptose / Lignée cellulaire tumorale / Potentiel de membrane mitochondriale Type d'étude: Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Yonsei Medical Journal Année: 2014 Type: Article