A decrease in the expression of CD63 tetraspanin protein elevates invasive potential of human melanoma cells
Experimental & Molecular Medicine
;
: 317-323, 2003.
Article
Dans Anglais
| WPRIM
| ID: wpr-13850
ABSTRACT
CD63, which belongs to the tetraspanin membrane proteins, has been proposed to play an important role in inhibiting melanoma metastasis. To determine whether reduction of CD63 expression, which frequently occurs in the malignant progression of human melanoma, is responsible for metastasis promotion, we transfected the antisense CD63 cDNA into MelJuso melanoma cells having endogenous CD63 expression. The antisense CD63 transfectant clones showing decreased CD63 expression displayed increased cell motility, matrix-degrading activity, and invasiveness in vitro when compared with the control transfectant cells. The antisense CD63 cDNA-transfected cells also exhibited altered adhesiveness to extracellular matrix. The results suggest that reduced CD63 expression contributes to the invasive and metastatic ability of human melanoma cells.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Glycoprotéines de membrane plaquettaire
/
Antigènes CD
/
Régulation de l'expression des gènes tumoraux
/
RT-PCR
/
Mélanome
/
Invasion tumorale
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2003
Type:
Article
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