A Recent Review of Tardive Dyskinesia: Focused on Basic Experimental Results / 대한정신약물학회지

ABSTRACT

Long-term treatment with antipsychotics can lead to a sometimes irreversible motor disorder, tardive dyskinesia(TD). Although TD is a serious side effect, the pathophysiology of it remains unclear. This article reviews recent experiments designed to determine the pathophysiology of TD. The review is divided into three parts; the first part describes the existing hypotheses on the pathophysiology of TD, the second part consists of the animal models of TD, and the third part consists of the other descriptions of the exerimental researches on TD. The challenge for the future is to integrate these data into a more complete understanding of the pathophysiology of TD.