Zonisamide Changes Unilateral Cortical Excitability in Focal Epilepsy Patients
Journal of Clinical Neurology
;
: 189-195, 2010.
Article
Dans Anglais
| WPRIM
| ID: wpr-139696
ABSTRACT
BACKGROUND AND PURPOSE:
To evaluate changes in cortical excitability induced by zonisamide (ZNS) in focal epilepsy patients.METHODS:
Twenty-four drug-nasmall yi, Ukrainianve focal epilepsy patients (15 males; overall mean age 29.8 years) were enrolled. The transcranial magnetic stimulation parameters obtained using two Magstim 200 stimulators were the resting motor threshold, amplitude of the motor-evoked potential (MEP), cortical silent period, short intracortical inhibition, and intracortical facilitation. These five transcranial magnetic stimulation parameters were measured before and after ZNS, and the findings were compared.RESULTS:
All 24 patients were treated with ZNS monotherapy (200-300 mg/day) for 8-12 weeks. After ZNS, MEP amplitudes decreased (-36.9%) significantly in epileptic hemispheres (paired t-test with Bonferroni's correction for multiple comparisons, p0.05). ZNS did not affect cortical excitability in nonepileptic hemispheres.CONCLUSIONS:
These findings suggest that ZNS decreases cortical excitability only in the epileptic hemispheres of focal epilepsy patients. MEP amplitudes may be useful for evaluating ZNS-induced changes in cortical excitability.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Épilepsies partielles
/
Stimulation magnétique transcrânienne
/
Isoxazoles
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Journal of Clinical Neurology
Année:
2010
Type:
Article
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