Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Endocrinology and Metabolism
;
: 331-334, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-141175
ABSTRACT
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rhabdomyolyse
/
Hémofiltration
/
Muscles squelettiques
/
Inhibiteurs de l'hydroxyméthylglutaryl-CoA réductase
/
Atteinte rénale aigüe
/
Hypercholestérolémie
/
Hypothyroïdie
/
Muscles
/
Myoglobine
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Endocrinology and Metabolism
Année:
2013
Type:
Article
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