What Number of Oocytes Is Appropriate for Defining Poor Ovarian Response?
Yonsei Medical Journal
;
: 482-489, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-141619
ABSTRACT
PURPOSE:
This study attempted to derive an objective and sophisticated definition of poor ovarian response (POR). MATERIALS ANDMETHODS:
A total of 176 consecutive in vitro fertilization (IVF) cycles (137 patients) with conventional ovarian stimulation during 2009 to 2012 were studied by retrospective analysis. Optimal oocyte number (total or mature) was determined by statistics-based (distribution of oocyte number) and prognosis-based approaches (prediction for IVF outcome). Receiver operating characteristics curve analysis was used to show what number of oocytes could predict IVF pregnancy and whether clinical and laboratory variables could predict newly defined POR.RESULTS:
The 25th percentile of the distribution corresponded to total oocytes 5 and mature oocyte >1. Considering the incidence of POR (34.1%), a reasonable definition of POR was decided as total oocytes < or =2 or mature oocyte < or =1. For the prediction of this new definition, the extreme cut-off value (by setting a false positive rate of 5%) of serum anti-Mullerian hormone (AMH) was < or =0.76 ng/mL, which was better than serum follicle stimulating hormone or age. A new simple definition of POR was derived as total oocytes < or =2 or mature oocyte < or =1 in a previous cycle or a serum AMH level of < or =0.76 ng/mL. When this simple criterion was re-applied to our data, the predictive performance was similar to the Bologna criteria.CONCLUSION:
We here propose a new definition of POR, which is simple and supported by statistical and prognostic analyses.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovocytes
/
Induction d'ovulation
/
Pronostic
/
Fécondation in vitro
/
Études rétrospectives
/
Courbe ROC
/
Résultat thérapeutique
/
Injections intracytoplasmiques de spermatozoïdes
/
Hormone antimullérienne
/
Hormone folliculostimulante
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Grossesse
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
2015
Type:
Article
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