The Effects of Preoperative or Postperitoneal Closure Epidural Ketamine on Epidural Anesthesia and Analgesia for Obstetric Patients / 대한마취과학회지
Korean Journal of Anesthesiology
;
: 276-281, 1999.
Article
Dans Coréen
| WPRIM
| ID: wpr-142554
ABSTRACT
BACKGROUND:
The NMDA receptor mediates wind-up and long-term potentiation in the responses of cells to prolonged stimuli; thus we postulated that the induction and maintenance of sensitization would be affected by the timing of epidural ketamine administration under epidural anesthesia.METHODS:
Sixty patients undergoing elective cesarian section were randomly and equally assigned to one of three groups. 20 ml of 2% lidocaine and 2 mg morphine with epinephrine was injected to all patients epidurally through an indwelling catheter inserted at the L2-3 interspace. Before surgical incision, the patients in group 1 were given 3 ml saline, while the patients in group 2 were given 30 mg ketamine. In group 3, patients were injected with 30 mg ketamine after peritoneal closure. An additional 2 mg morphine was injected into all patients 24 h after surgery. The analgesic effects were assessed and side effects were also evaluated.RESULTS:
VAS of group 3 at 3 24 h was lower than in the group 1, and at 6 24 h it was lower than in the group 2. The number of patients using additional analgesics in group 3 was lower than in the other groups. The incidence of nausea and vomiting was higher in the group 1 than in the other groups, but dizzness was higher in the groups 2 and 3 than in the control group.CONCLUSIONS:
Preoperative administration of epidural ketamine is less effective in reducing postoperative pain than when given after peritoneal closure, especially under epidural anesthesia with local anesthetics.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Douleur postopératoire
/
Vomissement
/
Épinéphrine
/
Cathéters à demeure
/
Incidence
/
N-Méthyl-aspartate
/
Potentialisation à long terme
/
Analgésie
/
Analgésiques
/
Anesthésie péridurale
Type d'étude:
Etude d'incidence
/
Étude pronostique
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Anesthesiology
Année:
1999
Type:
Article
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