Protective effects of Acanthopanax divaricatus extract in mouse models of Alzheimer's disease
Nutrition Research and Practice
;
: 386-390, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-142636
ABSTRACT
BACKGROUND:
Acanthopanax divaricatus var. albeofructus (ADA) extract has been reported to have anti-oxidant, immunomodulatory, and anti-mutagenic activity. MATERIALS/METHODS:
We investigated the effects of ADA extract on two mouse models of Alzheimer's disease (AD); intracerebroventricular injection of beta-amyloid peptide (Abeta) and amyloid precursor protein/presenilin 1 (APP/PS1)-transgenic mice.RESULTS:
Intra-gastric administration of ADA stem extract (0.25 g/kg, every 12 hrs started from one day prior to injection of Abeta1-42 until evaluation) effectively blocked Abeta1-42-induced impairment in passive avoidance performance, and Abeta1-42-induced increase in immunoreactivities of glial fibrillary acidic protein and interleukin (IL)-1alpha in the hippocampus. In addition, it alleviated the Abeta1-42-induced decrease in acetylcholine and increase in malondialdehyde levels in the cortex. In APP/PS1-transgenic mice, chronic oral administration of ADA stem extract (0.1 or 0.5 g/kg/day for six months from the age of six to 12 months) resulted in significantly enhanced performance of the novel-object recognition task, and reduced amyloid deposition and IL-1beta in the brain.CONCLUSIONS:
The results of this study suggest that ADA stem extract may be useful for prevention and treatment of AD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Encéphale
/
Acétylcholine
/
Administration par voie orale
/
Interleukines
/
Plaque amyloïde
/
Eleutherococcus
/
Maladie d'Alzheimer
/
Protéine gliofibrillaire acide
/
Hippocampe
/
Amyloïde
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Nutrition Research and Practice
Année:
2014
Type:
Article
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