Characteristics and Follow-up Results of the Window Period Blood Donors for Hepatitis C Virus / 대한수혈학회지
Korean Journal of Blood Transfusion
;
: 15-22, 2007.
Article
Dans Coréen
| WPRIM
| ID: wpr-14269
ABSTRACT
BACKGROUND:
To improve the safety of the blood supply in Korea, nucleic acid amplification testing (NAT) for HCV and HIV-1 as a blood screening test has been used by the Korean Red Cross since February 1st, 2005. Until October 31st 2006, a total of 4,037,618 donor samples had been tested and 436 cases showed reactivity for HCV RNA. Only 10 of these cases showed serologically negative antibody results.METHODS:
We investigated the characteristics and the follow-up results of the ten donors who showed HCV RNA reactivity and serologically negative results.RESULTS:
All the ten donors were identified to be "window period" blood donors with confirmation of their seroconversion by follow-up testing. The average RNA titer of the donors was 9.21x106 IU/mL. Five donors showed high levels of ALT. One donor showed the reversed pattern on the test results for antibody and RNA.CONCLUSION:
By detecting five cases of HCV "window period" infection, NAT has increased the safety of the Korean blood supply. But it is considered that NAT can not be a substitute serological test and an adequate follow-up strategy is required for verification of the accurate seroconversion time.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Croix-Rouge
/
Donneurs de tissus
/
Donneurs de sang
/
ARN
/
Tests sérologiques
/
Dépistage de masse
/
Études de suivi
/
VIH-1 (Virus de l'Immunodéficience Humaine de type 1)
/
Hépatite C
/
Hepacivirus
Type d'étude:
Etude diagnostique
/
Étude observationnelle
/
Étude pronostique
/
Étude de dépistage
Limites du sujet:
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Korean Journal of Blood Transfusion
Année:
2007
Type:
Article
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