Levels of Soluble Interleukin-2 Receptors in Serum of Patients with Behçet's Disease
Annals of Dermatology
;
: 13-16, 1993.
Article
Dans Anglais
| WPRIM
| ID: wpr-143582
ABSTRACT
BACKGROUND:
Interleukin-2 receptor (IL-2) is expressed and released predominantly activated T lymphocyte. Increased serum levels of soluble IL-2R have been noted in a variety of autoimmune diseases and in conditions associated with T lymphocyte activation.OBJECTIVE:
We aimed to examine whether the T lymphocyte activation has any association with the pathogenesis of Behçet's disease.METHOD:
We have measured the serum level of soluble IL-2R in serum samples obtained from 67 patients with Behçet's disease and 30 healthy people as a control group, using a double-antibody sandwich enzyme-linked immunosorbent assay technique.RESULTS:
Serum soluble IL-2R levels were found to be significantly elevated in the group of Behçet's disease as compared with the control group. No significant differences were found within clinical subtypes of Behçet's disease.CONCLUSION:
These findings suggest the presence of an ongoing T lymphocyte activation in this disease process.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladies auto-immunes
/
Test ELISA
/
Activation des lymphocytes
/
Lymphocytes
/
Récepteurs à l'interleukine-2
/
Interleukine-2
/
Méthodes
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of Dermatology
Année:
1993
Type:
Article
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