A Case of IgM Deficiency with B Cell Deficiency Detected by ABO Discrepancy in a Patient with Acute Osteomyelitis
Annals of Laboratory Medicine
;
: 208-211, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-144096
ABSTRACT
ABO discrepancy refers to an inconsistency between red cell and serum typings and has various causes, including hypogammaglobulinemia. IgM deficiency is a rare disorder that may accompany several conditions such as infection and autoimmune disorders. Here, we describe a case of IgM deficiency discovered during the evaluation of an ABO discrepancy in a 16-yr-old Korean boy. ABO blood grouping showed that while his cell type was O+, serum typing detected only anti-A (3+). Anti-B was not detectable at room temperature but was graded at 1+ at 4degrees C. ABO genotyping revealed an O/O genotype. His serum IgG, IgA, and IgM concentrations were 770 mg/dL (reference range 800-1,700 mg/dL), 244 mg/dL (reference range 100-490 mg/dL), and 13.5 mg/dL (reference range 50-320 mg/dL), respectively. He was diagnosed with acute osteomyelitis on the basis of clinical presentation and imaging studies. The symptoms gradually improved within 3 weeks of treatment. However, the ABO discrepancy and IgM deficiency persisted even 6 months after recovery and lymphocyte subset analysis revealed CD19+ B cell deficiency. To the best of our knowledge, IgM deficiency detected by ABO discrepancy in a patient with acute osteomyelitis has not been reported before.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ostéomyélite
/
Os et tissu osseux
/
Système ABO de groupes sanguins
/
Immunoglobuline A
/
Immunoglobuline G
/
Immunoglobuline M
/
Imagerie par résonance magnétique
/
Lymphocytes B
/
Maladie aigüe
/
Radiopharmaceutiques
Limites du sujet:
Adolescent
/
Humains
/
Mâle
langue:
Anglais
Texte intégral:
Annals of Laboratory Medicine
Année:
2013
Type:
Article
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