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Hypercalcemia Refractory to Pamidronate Associated with Metastatic Calcifications in Multiple Organs / 대한내과학회지
Korean Journal of Medicine ; : 545-550, 2013.
Article Dans Coréen | WPRIM | ID: wpr-144653
ABSTRACT
Paget's disease of bone (PDB) is a disorder featuring high-level bone turnover associated with the presence of disorganized and immature bone tissue with excessive levels of fibrosis. The risk of deformity is very high. The etiology of PDB is not well understood, but includes both genetic and environmental factors among which is bone trauma. Hypercalcemia can occur as a complication of PDB in patients who are immobilized and dehydrated. However, to date, no case of severe hypercalcemia with metastatic calcifications in multiple organs has been reported in any PDB patient. The drugs of choice for treatment of PDB are bisphosphonates. These drugs effectively suppress bone turnover. Patients with extensive PDB may require higher doses of bisphosphonates, and acquired resistance to a particular bisphosphonate may be overcome by use an alternative drug. Here, we report a case of suspicion of PDB. The patient presented with hypercalcemia and metastatic calcifications and his condition improved dramatically after treatment with zoledronic acid.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Maladie de Paget des os / Malformations / Plaies et blessures / Os et tissu osseux / Fibrose / Diphosphonates / Hypercalcémie / Imidazoles Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Medicine Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Maladie de Paget des os / Malformations / Plaies et blessures / Os et tissu osseux / Fibrose / Diphosphonates / Hypercalcémie / Imidazoles Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Medicine Année: 2013 Type: Article