Increased Vascular Endothelial Growth Factors in Nasopharyngeal Aspirates from Children with Acute RSV Bronchiolitis / 소아알레르기및호흡기학회지
Pediatric Allergy and Respiratory Disease
;
: 166-172, 2010.
Article
Dans Coréen
| WPRIM
| ID: wpr-148390
ABSTRACT
PURPOSE:
Viral infection is known as one of the dominant risk factors for wheezing in children hospitalized before 2 years of age. Although the major viral pathogen associated with wheezing is respiratory syncytial virus (RSV), the mechanisms of wheezing remain unclear. Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and vascular permeability. The aim of this study was to evaluate the relationship between VEGF concentration and wheezing in children with acute RSV bronchiolitis.METHODS:
Ninety-four children with acute bronchiolitis who were admitted to Korea University Anam Hospital were enrolled in this study. Based on the proven viral agents, children with bronchiolitis were divided into 2 groups those who were infected with RSV (RSV (+) group, n=51) and those who were not (RSV (-) group, n=43). A complete history taking, physical examination and routine laboratory tests were performed on all children. VEGF levels in serum and nasopharyngeal aspirates (NPA) were determined by ELISA.RESULTS:
NPA VEGF levels were significantly higher in the RSV (+) group than in the RSV (-) group (331.8+/-197.8 vs. 204.5+/-97.0 pg/mL, P=0.002). The duration of wheezing is significantly longer in the RSV (+) group than in the RSV (-) group (3.8+/-2.7 days vs. 2.4+/-1.8 days, P=0.037).CONCLUSION:
The results of this study suggest that children with RSV bronchiolitis may have significantly higher NPA VEGF levels than those without, which may be associated with a longer duration of wheezing in those with RSV bronchiolitis.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Examen physique
/
Virus respiratoires syncytiaux
/
Perméabilité capillaire
/
Test ELISA
/
Bronchiolite
/
Bruits respiratoires
/
Facteurs de risque
/
Facteurs de croissance endothéliale vasculaire
/
Facteur de croissance endothéliale vasculaire de type A
/
Corée
Type d'étude:
Etude d'étiologie
/
Facteurs de risque
Limites du sujet:
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Pediatric Allergy and Respiratory Disease
Année:
2010
Type:
Article
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