The Effect of Mitomycin C Trabeculectomy in Neovascular Glaucoma

ABSTRACT

The authors studied retrospectively the results of mitomycin C (MMC) trabeculectomy in 19 eyes with neovascular glaucoma which could be followed up more than 4 months after surgery. Twelve eyes(63%) were classified as success group and 7 eyes(37%) were classified as failure group. In the success group, the mean intraocular pressure(IOP) was significantly reduced from 52.1+/-10.1mmHg preoperatively to 10.1+/-3.8mmHg at last follow Kaplan-Meier survival analysis, cumulative success rates at 6 and 12 months intervals were 68%, 59% respectively. In the failure group, the mean IOP was reduced significantly from 51.9+/-8.1mmHg preoperatively to 26.6+/-13.4mmHg at last follow up. The mean number of medications to reduce IOP was also reduced from 2.6+/-0.5 preoperatively to 1.3+/-0.8 at last follow up. The causes for failure were inadequate IOP control in 5 eyes(26%), loss of light perception in 1 eye(5%), and reoperation to reduce IOP(5%). Complication included hypotony in 4 eyes(21%), late bleb leakage in 2 eyes(10.5%), spontaneous hyphema in 2 eyes(10.5%), cataract progression needing extraction in 2 eyes(10.5%). We think that MMC trabeculectomy may be the first choice procedure before doing cyclocyro-therapry or cyclodestructive procedure using laser.