Breakthrough in heart failure with preserved ejection fraction: are we there yet?
The Korean Journal of Internal Medicine
;
: 1-14, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-149380
ABSTRACT
Heart failure with preserved ejection fraction (HFPEF) is a global health problem of considerable socioeconomic burden. It is projected to worsen with the aging population worldwide. The lack of effective therapies underscores our incomplete understanding of this complex heterogeneous syndrome. A novel paradigm has recently emerged, in which central roles are ascribed to systemic inflammation and generalized endothelial dysfunction in the pathophysiology of HFPEF. In this review, we discuss the role of the endothelium in cardiovascular homeostasis and how deranged endothelial-related signaling pathways contribute to the development of HFPEF. We also review the novel therapies in various stages of research and development that target different components of this signaling pathway.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Débit systolique
/
Endothélium vasculaire
/
Transduction du signal
/
Facteurs de risque
/
Fonction ventriculaire gauche
/
Médiateurs de l'inflammation
/
Défaillance cardiaque
/
Inflammation
Type d'étude:
Etude d'étiologie
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
The Korean Journal of Internal Medicine
Année:
2016
Type:
Article
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