How to design intravenous anesthetic dose regimens based on pharmacokinetics and pharmacodynamics principles
Anesthesia and Pain Medicine
; : 235-244, 2015.
Article
de Ko
| WPRIM
| ID: wpr-149874
Bibliothèque responsable:
WPRO
ABSTRACT
Pharmacokinetics is the study of the rate and degree of drug transport to various tissues in the human body. Pharmacokinetic parameters summarize drug kinetics and ideally predict a clinical situation. A single kinetic profile may be summarized by peak concentration, peak time, half-life and area under the curve. Dosage regimens are designed to confer the maximum desired effects for the required time period with minimal toxicity. Target-controlled infusions use pharmacokinetic models to titrate intravenous anesthetic administration to achieve a desired drug concentration. Context-sensitive half time is used to predict the clinical time course, rather than terminal half-life. It is important that anesthesiologists understand the basic pharmacological principles and apply them in their daily clinical practice. This review discusses the ways in which anesthesiologists can design a patient-specific dosage regimen of intravenous anesthetics by utilizing basic concepts of pharmacokinetics and pharmacodynamics using pharmacokinetic simulations.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacocinétique
/
Corps humain
/
Anesthésiques intraveineux
/
Période
Type d'étude:
Prognostic_studies
langue:
Ko
Texte intégral:
Anesthesia and Pain Medicine
Année:
2015
Type:
Article