Influence of Panax ginseng on Alpha-Adrenergic Receptor of Benign Prostatic Hyperplasia / 대한배뇨장애요실금학회지
International Neurourology Journal
; : 179-186, 2014.
Article
Dans En
| WPRIM
| ID: wpr-149990
Responsable en Bibliothèque :
WPRO
ABSTRACT
PURPOSE: Benign prostatic hyperplasia (BPH) is the most common prostate problem in older men. The present study aimed to investigate the inhibitory effect of Panax ginseng C.A. Meyer (P. ginseng) on a rat model of testosterone-induced BPH. METHODS: The rats were divided into 3 groups (each group, n=10): control, testosterone-induced BPH (20 mg/kg, subcutaneous injection), and P. ginseng (200 mg/kg, orally) groups. After 4 weeks, all animals were sacrificed to examine the blood biochemical profiles, prostate volume, weight, histopathological changes, alpha-1D adrenergic receptor (Adra1d) mRNA expression, and epidermal growth factor receptor (EGFR) and B-cell CLL/lymphoma 2 (BCL2) protein expression. RESULTS: The group treated with P. ginseng showed significantly lesser prostate size and weight than the testosterone-induced BPH group. In addition, P. ginseng decreased the mRNA expression of Adra1d as well as the expression of EGFR and BCL2 in prostate tissue. CONCLUSIONS: These results suggest that P. ginseng may inhibit the alpha-1-adrenergic receptor to suppress the development of BPH.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Prostate
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Hyperplasie de la prostate
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Testostérone
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ARN messager
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Lymphocytes B
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Récepteurs alpha-1 adrénergiques
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Modèles animaux
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Récepteurs ErbB
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Panax
Type d'étude:
Prognostic_studies
Limites du sujet:
Animals
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Humans
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Male
langue:
En
Texte intégral:
International Neurourology Journal
Année:
2014
Type:
Article