Risk Factors for Post-Lumbar Puncture Headache in a Study of Alzheimer's Disease Biomarkers
Dementia and Neurocognitive Disorders
; : 12-16, 2015.
Article
de En
| WPRIM
| ID: wpr-150107
Bibliothèque responsable:
WPRO
ABSTRACT
BACKGROUND AND PURPOSE: In memory clinics, the lumbar puncture (LP) is increasingly being used to evaluate cerebrospinal fluid for biomarkers of Alzheimer's disease (AD). Post-lumbar puncture headache (PLPH) is the most frequent complication of LP, and can prove to be a barrier for the performance of LP. METHODS: We retrospectively collected data from 59 subjects (patients with AD and cognitively healthy controls) who were enrolled in a study aimed to identify AD biomarkers via LP. In order to determine whether subjects experienced PLPH, we assessed recorded follow-up telephone interviews. To analyze the association between the occurrence of PLPH and several demographic- and procedure-related factors, a multiple logistic regression analysis with backward stepwise method was performed. RESULTS: The overall frequency of PLPH was 49.15%. PLPH was more frequent in younger subjects and clinical diagnosis was associated with PLPH. The use of cutting-edge needles was also suggested as a statistically significant factor in the development of PLPH, and was determined to be the only factor that could be modified in order to lower the frequency of PLPH. CONCLUSIONS: Age, clinical diagnosis, and needle type were all determined to be predictive factors of PLPH.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Ponction lombaire
/
Marqueurs biologiques
/
Modèles logistiques
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Liquide cérébrospinal
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Entretiens comme sujet
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Études rétrospectives
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Facteurs de risque
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Études de suivi
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Diagnostic
/
Céphalée post-ponction durale
Type d'étude:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Qualitative_research
langue:
En
Texte intégral:
Dementia and Neurocognitive Disorders
Année:
2015
Type:
Article