Celiac Disease in a Predisposed Subject (HLA-DQ2.5) with Coexisting Graves' Disease
Endocrinology and Metabolism
; : 105-109, 2015.
Article
de En
| WPRIM
| ID: wpr-150111
Bibliothèque responsable:
WPRO
ABSTRACT
Celiac disease is an intestinal autoimmune disorder, triggered by ingestion of a gluten-containing diet in genetically susceptible individuals. The genetic predisposition is related to human leukocyte antigen (HLA) class II genes, especially HLA-DQ2-positive patients. The prevalence of celiac disease has been estimated to be ~1% in Europe and the USA, but it is rarer and/or underdiagnosed in Asia. We report a case of celiac disease in a predisposed patient, with a HLA-DQ2 heterodimer, and Graves' disease that was treated successfully with a gluten-free diet. A 47-year-old woman complained of persistent chronic diarrhea and weight loss over a 9 month period. Results of all serological tests and stool exams were negative. However, the patient was found to carry the HLA DQ2 heterodimer. Symptoms improved after a gluten-free diet was initiated. The patient has been followed and has suffered no recurrence of symptoms while on the gluten-free diet. An overall diagnosis of celiac disease was made in a genetically predisposed patient (HLA-DQ2 heterodimer) with Graves' disease.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Asie
/
Récidive
/
Tests sérologiques
/
Perte de poids
/
Maladie coeliaque
/
Maladie de Basedow
/
Prévalence
/
Gènes MHC de classe II
/
Prédisposition génétique à une maladie
/
Diagnostic
Type d'étude:
Diagnostic_studies
/
Prevalence_studies
Limites du sujet:
Female
/
Humans
Pays comme sujet:
Asia
/
Europa
langue:
En
Texte intégral:
Endocrinology and Metabolism
Année:
2015
Type:
Article