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Increase of Clostridium difficile in Community; Another Worrisome Burden for Public Health / 대한임상미생물학회지
Annals of Clinical Microbiology ; : 7-12, 2016.
Article Dans Coréen | WPRIM | ID: wpr-151568
ABSTRACT

BACKGROUND:

Increasing rates of Clostridium difficile infection (CDI) have been reported mainly in Europe and North America; however, only limited reports have originated in Korea. The current epidemiology of CDI in the community could help to understand the outpatient healthcare environment and to extend infection control measures to outpatient settings.

METHODS:

C. difficile isolates in NHIS Ilsan Hospital from 2012 to 2014 were included in this study. Clinical characteristics, acquisition types, and previous antimicrobial therapy were obtained via Electronic Medical Records. C. difficile culture was performed only in unformed stool. Toxin was positive by enzyme-linked fluorescent immunoassay (ELFA) in 247 specimens. In addition, toxin B and binary toxin gene were detected by PCR in 57 specimens. CDI was defined by toxigenic C. difficile isolation in unformed stool.

RESULTS:

In the previous 3 years, 251 unduplicated C. difficile cases have been detected; 168 healthcare facility- associated hospital onset (HCFA-HO), 45 healthcare facility-associated community onset (HCFA-CO), and 38 community-associated (CA). Toxin positive rates by ELFA for toxin A&B were HCFA-HO 50.6% (84/166), HCFA-CO 41.9% (18/43), and CA 42.1% (16/38). Toxin positive rate by PCR for tcdB were HCFA-HO 62.9% (22/35), HCFA-CO 69.2% (9/13), and CA 100% (9/9). No binary toxin (cdtA/cdtB) was detected in 57 cases.

CONCLUSION:

Community-associated CDI may be underestimated in Goyang province, Korea, especially by commonly used ELFA toxin assay. The spread of community-associated CDI should be recognized as an increasing burden of public health.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Patients en consultation externe / Dosage immunologique / Réaction de polymérisation en chaîne / Santé publique / Épidémiologie / Clostridioides difficile / Prévention des infections / Clostridium / Infections communautaires / Prestations des soins de santé Limites du sujet: Humains Pays comme sujet: Amérique du Nord / Asie / Europe langue: Coréen Texte intégral: Annals of Clinical Microbiology Année: 2016 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Patients en consultation externe / Dosage immunologique / Réaction de polymérisation en chaîne / Santé publique / Épidémiologie / Clostridioides difficile / Prévention des infections / Clostridium / Infections communautaires / Prestations des soins de santé Limites du sujet: Humains Pays comme sujet: Amérique du Nord / Asie / Europe langue: Coréen Texte intégral: Annals of Clinical Microbiology Année: 2016 Type: Article