Comparison of Radiation Adaptive Responses in Peripheral Lymphocytes of Patients Undergoing Tc-99m MDP and Tc-99m DTPA Scintigraphies / 대한핵의학회잡지
Korean Journal of Nuclear Medicine
;
: 252-259, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-151749
ABSTRACT
PURPOSE:
The purpose of this study was to compare the radiation adaptive response (RAR) in peripheral lymphocytes (PL) of patients induced by Tc.-99m MDP and Tc-99m DTPA scintigraphies. MATERIALS ANDMETHODS:
Lymphocytes from 45 patients (25 males, 20 females, mean age 44+/-18 years) were collected before and after scintigraphies using 740 MBq Tc-99m MDP (n=22) or Tc-99m L)TPA (n=23). Lympho-cytes from 20 controls (12 males, 8 females, mean age 43+/-7 years) were also callected. They were exposed to challenge dose of 2 Gy gamma-rays using a Cs-137 cell irradiator, Number of ring-form (R) and dicentric (D) chromosomes was counted under the light microscope. From them a representative score, Ydr, was calculated as Ydr=(D+R)/cells. Adaptation index (AI) was defined as difference of Ydr between unconditioned and conditioned lymphocytes. Ydr was also measured after an administration of cyclohexi-mide (CHM), a protein synthesis inhibitor, before challenge dose.RESULTS:
RAR was induced in both groups of patients. CHM abolished the adaptive response in both groups. AI of Tc-99m MDP group was significantly higher than that of Tc-99m DTPA group.CONCLUSION:
Tc-99m MDP induced RAR was more prominent than those induced by Tc-99m DTPA.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Lymphocytes
/
Médronate de technétium (99mTc)
/
Aberrations des chromosomes
/
Acide pentétique
Limites du sujet:
Femelle
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
Korean Journal of Nuclear Medicine
Année:
2000
Type:
Article
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