A Case of Acute Promyelocytic Leukemia with a De novo t(11;19) Chromosomal Translocation / 대한내과학회지
Korean Journal of Medicine
;
: S268-S272, 2011.
Article
Dans Coréen
| WPRIM
| ID: wpr-152515
ABSTRACT
Acute promyelocytic leukemia (APL), which is usually defined by the morphological features of the leukemic cells, is characterized by the t(15;17) (q22;q21) chromosomal translocation and disseminated intravascular coagulation. This specific translocation results in a new fusion transcript between the promyelocytic leukemia (PML) gene and the retinoic acid receptor-alpha (RARalpha) gene. Although the presence of this fusion gene can predict a favorable clinical response to all-trans-retinoic-acid (ATRA) treatment, APL with chromosomal translocations other than t(15;17) (q22;q21) is extremely rare and is associated with a poor prognosis. We experienced a case of APL with de novo t(11;19).
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pronostic
/
Translocation génétique
/
Trétinoïne
/
Leucémie aiguë promyélocytaire
/
Leucémies
/
Coagulation intravasculaire disséminée
/
Anatomopathologie moléculaire
Type d'étude:
Etude diagnostique
/
Étude pronostique
langue:
Coréen
Texte intégral:
Korean Journal of Medicine
Année:
2011
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS