Induction of thermogenic adipocytes: molecular targets and thermogenic small molecules
Experimental & Molecular Medicine
;
: e353-2017.
Article
Dans Anglais
| WPRIM
| ID: wpr-153369
ABSTRACT
Adipose tissue is a central metabolic organ that controls energy homeostasis of the whole body. White adipose tissue (WAT) stores excess energy in the form of triglycerides, whereas brown adipose tissue (BAT) dissipates energy in the form of heat through mitochondrial uncoupling protein 1 (Ucp1). A newly identified adipose tissue called ‘beige fat’ (BAT-like) is produced through a process called WAT browning. This tissue mainly resides in WAT depots and displays intermediate characteristics of both WAT and BAT. Since the recent discovery of BAT in the human body, along with the identification of molecular targets for BAT activation, stimulating energy expenditure has been considered as a great strategy to treat human obesity and metabolic diseases. Here we summarize recent findings regarding molecular targets and thermogenic small molecules that can stimulate BAT and increase energy expenditure, with an emphasis on possible therapeutic applications in humans.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Triglycéride
/
Tissu adipeux brun
/
Tissu adipeux
/
Adipocytes
/
Corps humain
/
Métabolisme énergétique
/
Tissu adipeux blanc
/
Température élevée
/
Homéostasie
/
Maladies métaboliques
Type d'étude:
Étude pronostique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Experimental & Molecular Medicine
Année:
2017
Type:
Article
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