Elevated Aurora Kinase A Protein Expression in Diabetic Skin Tissue
Archives of Plastic Surgery
;
: 35-39, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-153627
ABSTRACT
BACKGROUND:
Aurora kinase A (Aurora-A) plays an important role in the regulation of mitosis and cytokinesis. Dysregulated Aurora-A leads to mitotic faults and results in pathological conditions. No studies on Aurora-A expression in human diabetic skin tissue have been reported. In light of this, we explored the expression of Aurora-A in human diabetic skin tissue.METHODS:
Aurora-A protein was evaluated by western blotting in 6 human diabetic skin tissue and 6 normal skin specimens.RESULTS:
Increased expression of Aurora-A protein was detected in all diabetic skin tissue samples in both western blot analysis and immunohistochemical staining. However, in the case of the normal skin tissue, no bands of Aurora-A protein were detected in either the western blotting analysis or the immunohistochemical staining.CONCLUSIONS:
Thus far, there have been no studies on the expression of Aurora-A in diabetic skin tissue. However, we believe that oxidative DNA damage related to the expression of Aurora-A protein and Aurora-A could be involved inhuman diabetic skin tissue.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Peau
/
Altération de l'ADN
/
Technique de Western
/
Cytocinèse
/
Diabète
/
Aurora kinase A
/
Mitose
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Archives of Plastic Surgery
Année:
2014
Type:
Article
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