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Cytologic Features of Prostatic Adenocarcinoma in Urine: Comparison with Urothelial Carcinoma
Korean Journal of Pathology ; : 79-86, 2011.
Article Dans Anglais | WPRIM | ID: wpr-155011
ABSTRACT

BACKGROUND:

Prostate adenocarcinoma (PACa) cells are rarely identified in urine cytology specimens and might be easily overlooked or misdiagnosed as urothelial neoplasm when clinically unsuspected.

METHODS:

We reviewed 19 urine cytology specimens obtained from 13 patients with PACa and evaluated the characteristic features discriminating PACa from urothelial carcinoma (UCa). For comparison, 27 cases of high-grade UCa (HGUCa) and 10 cases of urothelial carcinoma in situ (UCis) were also evaluated.

RESULTS:

The urine cytologic evaluation of PACa revealed clustered cells forming 3-dimensional syncytial fragments with occasional microacinar grouping in a clean background. Most tumor cells were small and uniform with a high nuclear-to-cytoplasmic ratio and indistinct cell borders. The nuclei were round-to-oval and the cytoplasm was scanty and thin. One or more centrally-located prominent nucleoli were characteristically noted in one half of the cases. The nucleoli had a well-defined, large, round and eosinophilic appearance. In four high-grade cases, large tumor cells were encountered and had relatively monotonous cells with smooth-outlined cell clusters, well-defined and thin cytoplasm, and round nuclei with characteristic prominent nucleoli.

CONCLUSIONS:

Combining the information of prostate cancer and the recognition of cytomorphologic features of PACa will help differentiate PACa from HGUCa and UCis.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prostate / Tumeurs de la prostate / Épithélioma in situ / Carcinome transitionnel / Adénocarcinome / Brachyura / Cytoplasme / Granulocytes éosinophiles Type d'étude: Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Journal of Pathology Année: 2011 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Prostate / Tumeurs de la prostate / Épithélioma in situ / Carcinome transitionnel / Adénocarcinome / Brachyura / Cytoplasme / Granulocytes éosinophiles Type d'étude: Étude pronostique Limites du sujet: Humains langue: Anglais Texte intégral: Korean Journal of Pathology Année: 2011 Type: Article