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Rocuronium Pretreatment for Prevention of Myalgia Following Succinylcholine Administration / 대한마취과학회지
Korean Journal of Anesthesiology ; : 777-782, 1999.
Article Dans Coréen | WPRIM | ID: wpr-156206
ABSTRACT

BACKGROUND:

The purpose of this study was to assess the effect of rocuronium pretreatment on the succinylcholine induced biochemical changes and fasciculations, myalgia and to compare it with vecuronium pretreatment.

METHODS:

We have studied 60 patients undergoing minor elective surgery, in a prospective double blinded method. Three groups of 20 patients each were pretreated with saline 0.01 ml/kg (group C), rocuronium 0.05 mg/kg (group R), or vecuronium 0.007 mg/kg (group V). Three minutes after the pretreatment, 1.5 mg/kg succinylcholine was injected. Serum potassium five minutes after succinylcholine and creatine kinase 24 hr after operation were measured. Fasciculations and postoperative myalgia at 24 and 48 h were evaluated.

RESULTS:

The increase in creatine kinase and incidence of fasciculations were lowest in the rocuronium group (33 IU/L; 15%) and followed by vecuronium group (58 IU/L; 50%) and highest in the control group (101 IU/L; 100%). The increase in serum potassium concentration (0.3 mEq/L) was not attenuated by any regimen. The incidence of postoperative myalgia on day 1 and day 2 was lower in the rocuronium (40%, 30%) and the vecuronium (50%; 35%) group than control group (85%; 75%).

CONCLUSIONS:

Rocuronium pretreatment is more effective in reducing creatine kinase rise and fasciculations after succinylcholine than vecuronium. However rocuronium and vecuronium are also effective in preventing postoperative myalgia.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Suxaméthonium / Vécuronium / Incidence / Études prospectives / Creatine kinase / Fasciculation / Myalgie Type d'étude: Etude d'incidence / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Anesthesiology Année: 1999 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Suxaméthonium / Vécuronium / Incidence / Études prospectives / Creatine kinase / Fasciculation / Myalgie Type d'étude: Etude d'incidence / Étude observationnelle / Étude pronostique Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Anesthesiology Année: 1999 Type: Article