A study for diagnosis of squamous cell carcinoma arising from mature cystic teratoma / 대한산부인과학회지

ABSTRACT

OBJECTIVE: To evaluate factors for diagnosis of squamous cell carcinoma arising from ovarian mature cystic teratoma and whether squamous cell carcinoma (SCC) antigen, CA125, CA19-9 and CEA is useful for detection of the malignant transformation of mature cystic teratoma of ovary. METHODS: From October 1999 to December 2008, 11 patients with malignant transformation arising from ovarian mature cystic teratoma were treated at Departments of Obstetric and Gynecology in Samsung Medical Center. Demographic characteristics, symptoms, sign, preoperative images, stage, mode of therapy and results of follow up were reviewed retrospectively. RESULTS: The incidence of squamous cell carcinoma arising from ovarian mature cystic teratoma was 0.15% (11/7,345) in this hospital. The median age of patients was 60.8 years (range, 48~73 years). The most common preoperative diagnosis is mature cystic teratoma (n=5), followed by malignant transformation of mature cystic teratoma (n=3), colon cancer (n=2), primary epithelial ovarian cancer (n=1). SCC antigen level was elevated in five patients (45.4%) and CA125 was elevated in seven patients (63.6%). Median longitudinal diameter of ovarian tumors was 11.1 cm. All the patients were surgically staged. CONCLUSION: We should consider women, old aged and had large sized ovarian teratoma, were associated with development of malignant transformation of ovarian mature cystic teratomas, especially squamous cell carcinoma. CEA, CA19-9, and SCC antigen, in addition to CA125, should be used for tumor markers.