Evaluation of Arterial Impairment after Experimental Gelatin Sponge Embolization in a Rabbit Renal Model
Korean Journal of Radiology
;
: 133-138, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-157421
ABSTRACT
OBJECTIVE:
Arterial stenosis is a major obstacle for subsequent interventional procedures. We hypothesized that the stenosis is caused by gelatin sponge embolization and performed an experimental study in a rabbit renal model. MATERIALS ANDMETHODS:
A total of 24 rabbits were embolized with porcine gelatin sponge particles injected into the renal arteries. Four rabbits were sacrificed on 1 day, 4 days, 1 week, 2 weeks, 3 weeks, and 4 weeks after embolization. Microscopic evaluations were performed on hematoxylin-eosin and smooth muscle actin immunohistochemical stained sections.RESULTS:
Gelatin sponge particles were mainly observed in the segmental and interlobar arteries. Transmural inflammation of the embolized arterial wall and mild thickening of the media were observed 1 week after embolization. Resorption of the gelatin sponge and organization of thrombus accompanied by foreign body reactions, were observed from 2 to 4 weeks after embolization. Microscopic images of the 3 weeks group showed vessel lumens filled mostly with organized thrombi, resulting in severe stenosis. Additionally, vessels showed a thickened intima that contained migrating smooth muscle cells and accompanying interruption of the internal elastic lamina. The migrating smooth muscle cells were distributed around the recanalized arterial lumen.CONCLUSION:
Gelatin sponge embolization may induce arterial stenosis by causing organized thrombus and intimal hyperplasia, which consists of migrating smooth muscle cells and intimal collagen deposits.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Porifera
/
Artère rénale
/
Suidae
/
Sténose pathologique
/
Modèles animaux de maladie humaine
/
Embolisation thérapeutique
/
Gélatine
/
Éponge de gélatine résorbable
/
Rein
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Korean Journal of Radiology
Année:
2015
Type:
Article
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