Transarterial Chemoembolization Using Gelatin Sponges or Microspheres Plus Lipiodol-Doxorubicin versus Doxorubicin-Loaded Beads for the Treatment of Hepatocellular Carcinoma
Korean Journal of Radiology
; : 125-132, 2015.
Article
de En
| WPRIM
| ID: wpr-157422
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: To retrospectively compare treatment of hepatocellular carcinoma (HCC) with transarterial chemoembolization (TACE) using gelatin sponges or microspheres plus lipiodol-doxorubicin vs. doxorubicin-loaded drug-eluting beads (DEB). MATERIALS AND METHODS: A total of 158 patients with HCC received TACE from November 2010 to November 2011 were enrolled in this study, including 64 (40.5%) received TACE with lipiodol-doxorubicin and gelatin sponges (group A), 41 (25.9%) received TACE with lipiodol-doxorubicin and microspheres (group B), and 53 (33.5%) received TACE with doxorubicin-loaded DEB (group C). Tumor response and adverse events (AEs) were evaluated. RESULTS: No significant difference was found at baseline among the three groups. The doxorubicin dosage in group C was significantly (p < 0.001) higher compared to the dose used in groups A or B (median, 50 mg vs. 31 mg or 25 mg). Significantly (p < 0.001) more patients in group C achieved complete response compared to those in groups A or B (32.1% vs. 6.3% or 2.4%). Significantly (p < 0.001) less patients in group C had progressive disease compared to those in groups A or B (34.0% vs. 57.8% or 68.3%). Minor AEs were more common in groups A and B compared to group C, with rates of 54.7%, 34.1%, and 5.7%, respectively. CONCLUSION: In patients with HCC, TACE with DEB offers better safety and efficacy profiles compared to either TACE with gelatin sponges or TACE with microspheres.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Vecteurs de médicaments
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Doxorubicine
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Douleur abdominale
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Études rétrospectives
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Études de suivi
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Chimioembolisation thérapeutique
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Huile éthiodée
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Carcinome hépatocellulaire
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Survie sans rechute
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Estimation de Kaplan-Meier
Type d'étude:
Observational_studies
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Prognostic_studies
Limites du sujet:
Adult
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Aged
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Female
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Humans
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Male
langue:
En
Texte intégral:
Korean Journal of Radiology
Année:
2015
Type:
Article