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Helicobacter pylori Infection Enhances Gastric Mucosal Inflammation in Individuals Carrying the 260-T Allele of the CD14 Gene
Gut and Liver ; : 317-322, 2013.
Article Dans Anglais | WPRIM | ID: wpr-158234
ABSTRACT
BACKGROUND/

AIMS:

We aim to evaluate the association between promoter polymorphism of the clusters of differentiation 14 (CD14) gene and Helicobacter pylori-induced gastric mucosal inflammation in a healthy Korean population.

METHODS:

The study population consisted of 267 healthy subjects who visited our hospital for free nationwide gastric cancer screening. Promoter polymorphism at -260 C/T of the CD14 gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The severity of gastric mucosal inflammation was estimated by a gastritis score based on the sum of the values of the grade and activity of the gastritis. Expression of soluble CD14 (sCD14) was assessed by quantitative sandwich ELISA.

RESULTS:

CD14 polymorphism was not associated with H. pylori infection. There were no significant differences in gastritis scores among the genotype subgroups, but subjects carrying the CD14 -260 CT/TT genotype had significantly higher sCD14 levels than those carrying the CC genotype. Subjects with the 260-T allele of the CD14 gene and H. pylori infection had significantly higher sCD14 levels than those with the same genotype but without infection.

CONCLUSIONS:

In individuals with the T allele at the -260 site of the promoter region of the CD14 gene, H. pylori infection accentuates gastric mucosal inflammation.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Tumeurs de l'estomac / Polymorphisme de restriction / Dépistage de masse / Réaction de polymérisation en chaîne / Helicobacter pylori / Régions promotrices (génétique) / Helicobacter / Levage / Allèles Type d'étude: Étude pronostique / Étude de dépistage langue: Anglais Texte intégral: Gut and Liver Année: 2013 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Tumeurs de l'estomac / Polymorphisme de restriction / Dépistage de masse / Réaction de polymérisation en chaîne / Helicobacter pylori / Régions promotrices (génétique) / Helicobacter / Levage / Allèles Type d'étude: Étude pronostique / Étude de dépistage langue: Anglais Texte intégral: Gut and Liver Année: 2013 Type: Article