Helicobacter pylori Infection Enhances Gastric Mucosal Inflammation in Individuals Carrying the 260-T Allele of the CD14 Gene
Gut and Liver
;
: 317-322, 2013.
Article
Dans Anglais
| WPRIM
| ID: wpr-158234
ABSTRACT
BACKGROUND/AIMS:
We aim to evaluate the association between promoter polymorphism of the clusters of differentiation 14 (CD14) gene and Helicobacter pylori-induced gastric mucosal inflammation in a healthy Korean population.METHODS:
The study population consisted of 267 healthy subjects who visited our hospital for free nationwide gastric cancer screening. Promoter polymorphism at -260 C/T of the CD14 gene was determined by polymerase chain reaction and restriction fragment length polymorphism analysis. The severity of gastric mucosal inflammation was estimated by a gastritis score based on the sum of the values of the grade and activity of the gastritis. Expression of soluble CD14 (sCD14) was assessed by quantitative sandwich ELISA.RESULTS:
CD14 polymorphism was not associated with H. pylori infection. There were no significant differences in gastritis scores among the genotype subgroups, but subjects carrying the CD14 -260 CT/TT genotype had significantly higher sCD14 levels than those carrying the CC genotype. Subjects with the 260-T allele of the CD14 gene and H. pylori infection had significantly higher sCD14 levels than those with the same genotype but without infection.CONCLUSIONS:
In individuals with the T allele at the -260 site of the promoter region of the CD14 gene, H. pylori infection accentuates gastric mucosal inflammation.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polymorphisme génétique
/
Tumeurs de l'estomac
/
Polymorphisme de restriction
/
Dépistage de masse
/
Réaction de polymérisation en chaîne
/
Helicobacter pylori
/
Régions promotrices (génétique)
/
Helicobacter
/
Levage
/
Allèles
Type d'étude:
Étude pronostique
/
Étude de dépistage
langue:
Anglais
Texte intégral:
Gut and Liver
Année:
2013
Type:
Article
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