Effect of Botulinum Toxin Type A on Morphology of Salivary Glands in Patients with Cerebral Palsy
Annals of Rehabilitation Medicine
;
: 636-640, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-159266
ABSTRACT
OBJECTIVE:
To investigate the effect of botulinum toxin type A (BTXA) on drooling and the morphologic change of the salivary gland in patients with cerebral palsy.METHOD:
Eight cerebral palsy patients suffering from severe drooling participated in this study. BTXA was injected into both submandibular and parotid glands under intravenous sedation and with ultrasound guidance (1 unit/gland/kg maximum 100 units) in an outpatient or inpatient procedure. The severity of drooling was measured before injection and 3 weeks after injection using the Teacher Drooling Scale, the Drooling Score-severity, frequency and the Visual Analog Scale. To investigate the morphologic change of the salivary glands, the size of salivary glands were measured before injection and 3 weeks after injection using computed tomography of the neck. The measurement values were analyzed by Wilcoxon signed rank test.RESULTS:
Statistically significant improvements were shown in all three parameters for assessing the severity of drooling after BTXA injections (p<0.05). Size of the salivary glands were significantly decreased at 3 weeks after BTXA injection (p<0.05).CONCLUSION:
Salivary gland injection with BTXA could be a useful treatment method to reduce drooling in patients with cerebral palsy and decreased size of salivary glands may partially explain the mechanism.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Patients en consultation externe
/
Glande parotide
/
Glandes salivaires
/
Ptyalisme
/
Stress psychologique
/
Toxines botuliniques
/
Paralysie cérébrale
/
Toxines botuliniques de type A
/
Patients hospitalisés
/
Cou
Type d'étude:
Guide de pratique
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of Rehabilitation Medicine
Année:
2011
Type:
Article
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