The Clinical Types and Characteristics of Diabetes Mellitus in Korean Children
Journal of the Korean Pediatric Society
;
: 1591-1598, 2000.
Article
Dans Coréen
| WPRIM
| ID: wpr-159509
ABSTRACT
PURPOSE:
Diabetic children should be classified into type 1 or 2 for adequate diabetic control. However, there is a shortage of information of the appropriate criteria in Korea. This study is desinged to discover the clinical types and characteristics of diabetes mellitus(DM) in Korean children.METHODS:
We studied the clinical characteristics and laboratory findings of 177 diabetic children. Classification was based on the serum C-peptide levels, presence of ketoacidosis, autoantibodies, and insulin dependence.RESULTS:
Among 177 diabetic children, 147(83.1%) were classified as type 1 and 21(11.9%) as type 2, and 12(57.1%) children in type 2 were obese. All patients with age of onset before 9 were type 1. In cases of type 1, initial serum C-peptide levels were 1.0ng/mL (6%). All patients with initial serum C-peptide level above 1.5ng/mL were type 2. Four patients initially diagnosed as type 2 DM changed to type 1 during follow-up, and 2 patients of type 1 DM changed to type 2. Only 55.4% of type 1 DM patients had insulin autoantibody, islet cell cytoplasmic antibody or anti-glutamic acid decarboxylase antibodies.CONCLUSION:
Most diabetic children in Korea were classified as type 1. Our results suggest that insulin requiring lean patients with positive autoantibody should be classified as type 1 even if their serum C-peptide levels are within normal range, and the clinical types could be changed during follow-up in a small proportion of diabetic children.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Valeurs de référence
/
Autoanticorps
/
Peptide C
/
Études de suivi
/
Ilots pancréatiques
/
Classification
/
Âge de début
/
Cytoplasme
/
Diabète
/
Insuline
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Coréen
Texte intégral:
Journal of the Korean Pediatric Society
Année:
2000
Type:
Article
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