Significant adverse reactions to long-acting gonadotropin-releasing hormone agonists for the treatment of central precocious puberty and early onset puberty
Annals of Pediatric Endocrinology & Metabolism
;
: 135-140, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-16061
ABSTRACT
PURPOSE:
Long-acting gonadotropin-releasing hormone agonists (GnRHa) are commonly used to treat central precocious puberty (CPP) in Korea. Although rare, there have been reports on the characteristic of adverse reactions of GnRHa in CPP among the Korean population. This study was intended to report on our clinical experience regarding significant adverse reactions to long-acting GnRHa in CPP and early onset puberty and to evaluate the prevalence rate of serious side effects.METHODS:
This retrospective study included children with CPP and early onset puberty, who were administered monthly with long-acting GnRHa (leuprolide acetate, triptorelin acetate) at the outpatient clinic of Department of Pediatrics, at Inha University Hospital, between January 2011 and December 2013. We analyzed the clinical characteristics of patients who experienced significant adverse reactions and evaluated the prevalence rate.RESULTS:
Six serious side effects (0.9%) were observed among total of 621 CPP and early onset puberty children with GnRHa therapy. The number of sterile abscess formation was four in three patients (4 events of 621). Anaphylaxis occurred in only one patient, and unilateral slipped capital femoral epiphysis (SCFE) in another one patient. Anaphylaxis occurred after the 6th administration of the monthly depot triptorelin acetate. Unilateral SCFE developed in GnRHa therapy.CONCLUSION:
Sterile abscess formation occurred in 0.6% of CPP and early onset puberty patients from the administration of a monthly depot GnRHa therapy. The occurrences of anaphylaxis and SCFE are extremely rare, but can have serious implications on patients. Clinicians should be aware of these potential adverse effects related to GnRHa therapy in CPP.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pédiatrie
/
Puberté précoce
/
Prévalence
/
Études rétrospectives
/
Hormone de libération des gonadotrophines
/
Puberté
/
Leuprolide
/
Pamoate de triptoréline
/
Abcès
/
Effets secondaires indésirables des médicaments
Type d'étude:
Étude observationnelle
/
Étude de prévalence
Limites du sujet:
Adolescent
/
Enfant
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Annals of Pediatric Endocrinology & Metabolism
Année:
2014
Type:
Article
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