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DEAD/DExH-Box RNA Helicases in Selected Human Parasites
The Korean Journal of Parasitology ; : 583-595, 2015.
Article Dans Anglais | WPRIM | ID: wpr-160904
ABSTRACT
DEAD/DExH-box RNA helicases catalyze the folding and remodeling of RNA molecules in prokaryotic and eukaryotic cells, as well as in many viruses. They are characterized by the presence of the helicase domain with conserved motifs that are essential for ATP binding and hydrolysis, RNA interaction, and unwinding activities. Large families of DEAD/DExH-box proteins have been described in different organisms, and their role in all molecular processes involving RNA, from transcriptional regulation to mRNA decay, have been described. This review aims to summarize the current knowledge about DEAD/DExH-box proteins in selected protozoan and nematode parasites of medical importance worldwide, such as Plasmodium falciparum, Leishmania spp., Trypanosoma spp., Giardia lamblia, Entamoeba histolytica, and Brugia malayi. We discuss the functional characterization of several proteins in an attempt to understand better the molecular mechanisms involving RNA in these pathogens. The current data also highlight that DEAD/DExH-box RNA helicases might represent feasible drug targets due to their vital role in parasite growth and development.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Parasites / ARN / Régulation de l'expression des gènes / RNA helicases / Eucaryotes Limites du sujet: Animaux langue: Anglais Texte intégral: The Korean Journal of Parasitology Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Parasites / ARN / Régulation de l'expression des gènes / RNA helicases / Eucaryotes Limites du sujet: Animaux langue: Anglais Texte intégral: The Korean Journal of Parasitology Année: 2015 Type: Article