Experimental Study for Measurement of Ureteral Compliance in Rat / 대한비뇨기과학회지

ABSTRACT

The compliance of upper urinary tract plays a main role in preservation of renal function against pressure overload. It consists of renal pelvic compliance and ureteral compliance. We measured ureteral compliance in rat with new experimental model applying pressure-flow study. Two catheters were placed in left renal pelvis. one for flow infusion, another for pressure monitoring. Pressure-flow study was done with ligation of uretero-vesical junction(UVJ) and subsequent pressure-flow study with ligation of uretero-pelvic junction(UPJ) in the same rat. Ureteral compliance was calculated from upper urinary tract compliance with UVJ ligation minus pelvic compliance with UPJ ligation. The data from seven rats were analyzed. Mean ureteral compliance (+/-standard deviation) was 0.0011+/-0.00034 ml/cmH2O and mean contribution of ureter for upper urinary tract compliance was 19%. Our new experimental model for measurement of ureteral compliance was simple and easy to perform. Results in this study will be used as baseline data for further investigation of uretera1 compliance in chronic partial ureteral obstruction.