An Association between 609 C --> T Polymorphism in NAD(P)H: Quinone Oxidoreductase 1 (NQO1) Gene and Blood Glucose Levels in Korean Population / 당뇨병
Korean Diabetes Journal
;
: 24-30, 2009.
Article
Dans Coréen
| WPRIM
| ID: wpr-161248
ABSTRACT
BACKGROUND:
NAD(P)H quinone oxidoreductase 1 (NQO1), which is an obligate two-electron reductase that utilizes NAD(P)H as an electron donor and is involved in the protection against oxidative stress, is likely involved in beta-cell destruction. We evaluated the frequency of the NQO1 polymorphism and its association with blood glucose levels.METHODS:
Genotypes were determined using a polymerase chain reaction restriction fragment length polymorphism-based assay in 56 patients and 48 healthy subjects. Fasting blood glucose, insulin, and lipid profiles were measured and homeostasis model assessment (HOMA)-insulin resistance (IR) was calculated from fasting glucose and insulin levels in the healthy subjects.RESULTS:
The genotype frequencies of NQO1 polymorphism were C/C (56.7%), C/T (42.3%), and T/T (1.0%). There were no associations between the NQO1 polymorphism and body mass index, blood pressure, lipid profile, HbA1c, postprandial glucose, and HOMA-IR. However, NQO1 mutants (C/T and T/T) showed weak but significantly higher fasting blood glucose levels compared with wild type (C/C).CONCLUSION:
Our data suggest that NQO1 609 C --> T polymorphism may be associated with glucose metabolism.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxidoreductases
/
Donneurs de tissus
/
Glycémie
/
Pression sanguine
/
Indice de masse corporelle
/
Réaction de polymérisation en chaîne
/
Benzoquinones
/
Jeûne
/
Stress oxydatif
/
Polymorphisme de nucléotide simple
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Korean Diabetes Journal
Année:
2009
Type:
Article
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