Relationship of Vascular Factors on Electrophysiologic Severity of Diabetic Neuropathy
Annals of Rehabilitation Medicine
;
: 56-65, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-16126
ABSTRACT
OBJECTIVE:
To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN).METHODS:
Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of DPN from 1 (normal) to 4 (severe) based on electrophysiologic findings. We collected the data concerning vascular factors (including brachial-ankle pulse wave velocity [PWV], ankle brachial index, ultrasound of carotid artery, lipid profile from the blood test, and microalbuminuria [MU] within 24 hours urine), and metabolic factors of diabetes (such as glycated hemoglobin [HbA1c]). We analyzed the differences among the four subgroups using χ2 test and ANOVA, and ordinal logistic regression analysis was performed to investigate the relationship between significant variables and severity of DPN.RESULTS:
The severity of DPN was significantly associated with duration of diabetes, HbA1c, existence of diabetic retinopathy and nephropathy, PWV, presence of plaque, low density lipoprotein-cholesterol and MU (p<0.05). Among these variables, HbA1c and presence of plaque were more significantly related with severity of DPN in logistic regression analysis (p<0.001), and presence of plaque showed the highest odds ratio (OR=2.52).CONCLUSION:
Our results suggest that markers for vascular wall properties, such as PWV and presence of plaque, are significantly associated with the severity of DPN. The presence of plaque was more strongly associated with the severity of DPN than other variables.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Hémoglobine glyquée
/
Artères carotides
/
Modèles logistiques
/
Odds ratio
/
Études rétrospectives
/
Échographie
/
Sténose carotidienne
/
Angiopathies diabétiques
/
Neuropathies diabétiques
/
Rétinopathie diabétique
Type d'étude:
Etude diagnostique
/
Etude d'étiologie
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of Rehabilitation Medicine
Année:
2016
Type:
Article
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