Non-Thermal Atmospheric-Pressure Plasma Possible Application in Wound Healing
Biomolecules & Therapeutics
;
: 477-490, 2014.
Article
Dans Anglais
| WPRIM
| ID: wpr-16139
ABSTRACT
Non-thermal atmospheric-pressure plasma, also named cold plasma, is defined as a partly ionized gas. Therefore, it cannot be equated with plasma from blood; it is not biological in nature. Non-thermal atmospheric-pressure plasma is a new innovative approach in medicine not only for the treatment of wounds, but with a wide-range of other applications, as e.g. topical treatment of other skin diseases with microbial involvement or treatment of cancer diseases. This review emphasizes plasma effects on wound healing. Non-thermal atmospheric-pressure plasma can support wound healing by its antiseptic effects, by stimulation of proliferation and migration of wound relating skin cells, by activation or inhibition of integrin receptors on the cell surface or by its pro-angiogenic effect. We summarize the effects of plasma on eukaryotic cells, especially on keratinocytes in terms of viability, proliferation, DNA, adhesion molecules and angiogenesis together with the role of reactive oxygen species and other components of plasma. The outcome of first clinical trials regarding wound healing is pointed out.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plasma sanguin
/
Peau
/
Maladies de la peau
/
Cicatrisation de plaie
/
Plaies et blessures
/
ADN
/
Kératinocytes
/
Survie cellulaire
/
Espèces réactives de l'oxygène
/
Cellules eucaryotes
langue:
Anglais
Texte intégral:
Biomolecules & Therapeutics
Année:
2014
Type:
Article
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