Localized Proton MR Spectroscopic Detection of Nonketotic Hyperglycinemia in an Infant
Korean Journal of Radiology
;
: 239-242, 2001.
Article
Dans Anglais
| WPRIM
| ID: wpr-161547
ABSTRACT
Nonketotic hyperglycinemia (NKH) is a rare metabolic brain disease caused by deficient activity of the glycine cleveage system. Localized proton MR spectroscopy (echo-time 166 msec), performed in an infant with the typical clinical and biochemical features of neonatal NKH, showed a markedly increased peak intensity at 3.55 ppm, which was assigned to glycine. Serial proton MR spectrosocpic studies indicated that glycine/choline and glycine/total creatine ratios correlated closely with the patient's clinical course. Proton MR spectroscopy was useful for the non-invasive detection and monitoring of cerebral glycine levels in this infant with NKH.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protons
/
Imagerie par résonance magnétique
/
Spectroscopie par résonance magnétique
/
Hyperglycinémie non cétosique
Type d'étude:
Etude diagnostique
Limites du sujet:
Humains
/
Mâle
/
Nouveau-né
langue:
Anglais
Texte intégral:
Korean Journal of Radiology
Année:
2001
Type:
Article
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