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Metronomic oral paclitaxel shows anti-tumor effects in an orthotopic mouse model of ovarian cancer / 부인종양
Journal of Gynecologic Oncology ; : 130-135, 2014.
Article Dans Anglais | WPRIM | ID: wpr-16238
ABSTRACT

OBJECTIVE:

The purpose of this study was to compare the in vivo anti-tumor efficacy of a mucoadhesive, lipid-based, oral paclitaxel formulation (DHP107) with traditional, intraperitoneal (IP) paclitaxel using an orthotopic mouse model of chemotherapy-sensitive SKOV3ip1 ovarian cancer.

METHODS:

To determine the optimal therapeutic dose of oral paclitaxel, DHP107 was administered per os to female athymic nude mice at 0, 25, or 50 mg/kg twice per week. Control mice received 100 microL saline once per week. IP injections of paclitaxel at 5 mg/kg once per week were used for comparison. To evaluate the potential therapeutic effect of metronomic DHP107 chemotherapy, mice received DHP107 50 mg/kg once per week per os, which was compared with 25 mg/kg twice per week and with vehicle-treated controls.

RESULTS:

Low-dose DHP107 (25 mg/kg) twice per week was as effective as IP paclitaxel (5 mg/kg once a week) but high-dose DHP107 (50 mg/kg once per week) was less effective at inhibiting tumor growth in an orthotopic mouse model (88%, 82%, and 36% decrease in tumor weight, respectively). Mice that received 25 mg/kg DHP107 twice per week or 50 mg/kg DHP107 once per week per os had a significant decrease in tumor weight compared with vehicle-treated controls (p<0.01, both doses).

CONCLUSION:

Metronomic oral chemotherapy with DHP107 showed anti-tumor efficacy in vivo similar to IP paclitaxel in an orthotopic mouse model.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs de l&apos;ovaire / Paclitaxel / Charge tumorale / Traitement médicamenteux / Souris nude Limites du sujet: Animaux / Femelle / Humains langue: Anglais Texte intégral: Journal of Gynecologic Oncology Année: 2014 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Tumeurs de l&apos;ovaire / Paclitaxel / Charge tumorale / Traitement médicamenteux / Souris nude Limites du sujet: Animaux / Femelle / Humains langue: Anglais Texte intégral: Journal of Gynecologic Oncology Année: 2014 Type: Article