Dopamine Transporter Density of the Basal Ganglia in Children with Attention Deficit Hyperactivity Disorder Assessed with I-123 IPT SPECT / 대한정신약물학회지
Korean Journal of Psychopharmacology
;
: 95-103, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-162865
ABSTRACT
OBJECTIVE:
ADHD has been known as a psychiatric disorder in childhood associated with dopamine dysregulation. In the present study, we investigated dopamine transporter (DAT) density using I-123N-(3-iodopropen-2-yl)-2beta-carbomethoxy-3beta-(4-chlorophenyl) tropane (I-123-IPT)-SPECT in children with ADHD on the hypothesis that alterations of DAT density in the basal ganglia were suggestive of dopaminergic dysfunction in children with ADHD.METHODS:
Nine drug-naive children with ADHD and six normal children were included in the study. We performed brain SPECT two hours after the intravenous administration of I-123-IPT and made both quantitative and qualitative analyses using the obtained SPECT data, which were reconstructed for the assessment of specific/nonspecific DAT binding ratios in the basal ganglia. We then investigated the correlation between ADHD Rating Scale (ARS) scores of children with ADHD and specific/nonspecific DAT binding ratios in the basal ganglia.RESULTS:
Children with ADHD had significantly greater specific/nonspecific DAT binding ratio of the basal ganglia comparing to normal children. However, no significant correlation were found between ARS scores of children with ADHD and specific/nonspecific DAT binding ratio of basal ganglia in children with ADHD.CONCLUSION:
These findings support the complex dysregulation of the dopaminergic neurotransmitter system in children with ADHD.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Trouble déficitaire de l'attention avec hyperactivité
/
Noyaux gris centraux
/
Encéphale
/
Dopamine
/
Tomographie par émission monophotonique
/
Agents neuromédiateurs
/
Transporteurs de la dopamine
/
Administration par voie intraveineuse
Type d'étude:
Recherche qualitative
Limites du sujet:
Enfant
/
Humains
langue:
Coréen
Texte intégral:
Korean Journal of Psychopharmacology
Année:
2002
Type:
Article
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