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Influence of Age, Rate of Obesity, Hepatic Function and Renal Function on Serum Prostate-Specific Antigen in Men Older than 50 Years / 대한비뇨기과학회지
Korean Journal of Urology ; : 1284-1290, 2001.
Article Dans Coréen | WPRIM | ID: wpr-163084
ABSTRACT

PURPOSE:

We investigated the influence of age, rate of obesity, hepatic function and renal function on serum prostate-specific antigen in healthy men older than 50 years. MATERIALS AND

METHODS:

From January 1999 to December 2000, 2,296 healthy Korean men older than 50 years who visited Health Promotion Center at our hospital for a routine health checkup were entered into a prospective study. All men underwent detailed clinical examinations, including serum prostate-specific antigen (PSA) determination using Hybritech Tandem-R assay, anthropometric measurements, tests for liver disease, tests for renal function, and other constitutes. We determined the risk factors of the increase of serum PSA among these clinical parameters using univariate and multivariate logistic regression analyses.

RESULTS:

The univariate logistic regression analysis indicated that age, alanine aminotransferase (ALT), hemoglobin, potassium, albumin, high-density lipoprotein (HDL) were the risk factors of the increase of serum PSA. In the multivariate model used, age, ALT, alkaline phosphatase, albumin, HDL and cholesterol were an independent predictors of the increase of serum PSA, whereas hemoglobin and potassium lost their statistical significance.

CONCLUSIONS:

Our findings suggest that the health status as well as may influence on serum PSA level of healthy men older than 50 years. Additional work is needed to determine and validate the clinical significance of these findings.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Modèles logistiques / Cholestérol / Études prospectives / Facteurs de risque / Antigène spécifique de la prostate / Alanine transaminase / Phosphatase alcaline / Promotion de la santé / Lipoprotéines Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains / Mâle langue: Coréen Texte intégral: Korean Journal of Urology Année: 2001 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Potassium / Modèles logistiques / Cholestérol / Études prospectives / Facteurs de risque / Antigène spécifique de la prostate / Alanine transaminase / Phosphatase alcaline / Promotion de la santé / Lipoprotéines Type d'étude: Etude d'étiologie / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains / Mâle langue: Coréen Texte intégral: Korean Journal of Urology Année: 2001 Type: Article