The Frequency and the Course of the Adverse Effects of Azathioprine/6-Mercaptopurine Treatment in Patients with Inflammatory Bowel Disease / 대한소화기학회지
The Korean Journal of Gastroenterology
;
: 291-297, 2008.
Article
Dans Coréen
| WPRIM
| ID: wpr-163685
ABSTRACT
BACKGROUND/AIMS:
This study was to evaluate the frequency and the course of the adverse effects of AZA/6-MP in Korean patients with inflammatory bowel disease (IBD).METHODS:
Medical records of the patients with IBD treated with AZA/6-MP at Severance hospital from June 1996 to September 2006 were retrospectively analyzed.RESULTS:
A total of 133 patients were studied. Male to female ratio was 1.31. The mean age was 31.7+/-10.9 year. Adverse effects included leukopenia occurred in 75 cases (56.4%), nausea/vomiting in 32 cases (24.1%), arthralgia in 6 cases (4.5%), hepatitis in 6 cases (4.5%), skin rash in 4 cases (3.0%), herpes zoster in 3 cases (2.3%), and headache in 1 case (0.8%). Most of leucopenia (58.7%) developed within 3 months after maximal tolerated dose of AZA/6-MP and nausea/vomiting frequently occurred within 3 months after start of AZA/6-MP treatment. Thirty-eight patients (28.6%) required the discontinuation of medication due to adverse effects.CONCLUSIONS:
Leukopenia was the most common adverse effect of AZA/6-MP treatment. Leukopenia and nausea/vomiting developed frequently in the early period of treatment of AZA/6-MP in patients with IBD. AZA/6-MP should be used cautiously to scrutinize bone marrow suppression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Azathioprine
/
Facteurs temps
/
Maladies inflammatoires intestinales
/
Maladie de Behçet
/
Études rétrospectives
/
Études de cohortes
/
Association de médicaments
/
Immunosuppresseurs
/
Leucopénie
/
Mercaptopurine
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Étude pronostique
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Coréen
Texte intégral:
The Korean Journal of Gastroenterology
Année:
2008
Type:
Article
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