Clinical Features of Drug-induced Liver Injury According to Etiology
Journal of Korean Medical Science
; : 1815-1820, 2015.
Article
Dans En
| WPRIM
| ID: wpr-164153
Responsable en Bibliothèque :
WPRO
ABSTRACT
Drug-induced liver injury (DILI) is an increasingly common cause of acute hepatitis. We examined clinical features and types of liver injury of 65 affected patients who underwent liver biopsy according DILI etiology. The major causes of DILI were the use of herbal medications (43.2%), prescribed medications (21.6%), and traditional therapeutic preparations and dietary supplements (35%). DILI from herbal medications, traditional therapeutic preparations, and dietary supplements was associated with higher elevations in aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels than was DILI from prescription medications. The types of liver injury based on the R ratio were hepatocellular (67.7%), mixed (10.8%), and cholestatic (21.5%). Herbal medications and traditional therapeutic preparations were more commonly associated with hepatocellular liver injury than were prescription medications (P = 0.002). Herbal medications and traditional therapeutic preparations induce more hepatocellular DILI and increased elevations in AST and ALT than prescribed medications.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Aspartate aminotransferases
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Études rétrospectives
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Compléments alimentaires
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Préparations à base de plantes
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Alanine transaminase
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Médicaments sur ordonnance
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Lésions hépatiques dues aux substances
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République de Corée
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Phytothérapie
Type d'étude:
Etiology_studies
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Observational_studies
Limites du sujet:
Adult
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Female
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Humans
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Male
Pays comme sujet:
Asia
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2015
Type:
Article